Harry saves Lily's life when Voldemort comes for them, but this has impacting consequences. Wanting to distance himself, Harry locks himself away until he's finally forced out into the open by his name being called from the Goblet of Fire. This happens in 5th year in my story.
Forced into hiding in the ruins of Hogwarts once Voldemort makes his move and takes over, Hermione is forced to give up her wand in an effort to fight off those seeking to kill muggleborns and destroy Voldemort and his horcruxes for good.